The retired 39-year-old will donate face masks, hand sanitisers, soaps and food through his Samuel Eto’o foundation.
The vital supplies will be sent to 50,000 households across four cities in the African nation – Douala, Buea, Yaoundé and Bafoussam.
Additionally, 50,000 face masks will be provided for taxi drivers who are at increased risk of catching the disease.
A statement from the foundation read: ‘This is a serious humanitarian crisis and only via proper sanitisation and the distribution of health kits can we curb the corona virus.’
All sporting activities have been suspended in Cameroon while the country deals with the virus, and its borders have been closed.
Eto’o picked up 118 caps for Cameroon, scoring 56 times and featuring at four World Cups.
He last played professionally for Qatar SC in the 2018-19 season for one season before calling time on his 22-year football career.